However, the fusion of autophagosomes with lysosomes was inhibited by Cd both in vivo and in vitro. It indicated that Cd triggered lysosomal activation.
Subsequently, the study investigated the effects of Cd on lysosomes and found that Cd induced lysosomal acidification, promoted the expression of lysosomal-associated membrane protein 2 and lysosomal hydrolase cathepsin B both in vivo and in vitro, and enhanced the lysosomal degradation capacity. In addition, it found that Cd induced autophagy but also caused autophagy blockade, and autophagy blockade intensified Cd-induced injury in liver cells. This study aimed to further confirm the hepatotoxic effects of Cd in mouse liver cells by various methods both in vivo and in vitro.
Previous studies have shown that Cd can induce liver cell injury however, the toxicity mechanisms of Cd have not been fully elucidated. Cadmium (Cd) is an important environmental pollutant.
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